Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q15915
UPID:
ZIC1_HUMAN
Alternative names:
Zinc finger protein 201; Zinc finger protein of the cerebellum 1
Alternative UPACC:
Q15915; Q2M3N1
Background:
Zinc finger protein ZIC 1, also known as Zinc finger protein 201 and Zinc finger protein of the cerebellum 1, plays a pivotal role in neurogenesis and organogenesis of the CNS. It is crucial for the early development of the dorsal spinal cord and cerebellum maturation, influencing the spatial distribution of mossy fiber neurons within the pontine gray nucleus and regulating their axon pathway choices.
Therapeutic significance:
Linked to diseases such as Craniosynostosis 6 and Structural brain anomalies with impaired intellectual development and craniosynostosis, Zinc finger protein ZIC 1's understanding could pave the way for innovative therapeutic strategies targeting these genetic disorders.