Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q15928
UPID:
ZN141_HUMAN
Alternative names:
-
Alternative UPACC:
Q15928; Q6DK07
Background:
Zinc finger protein 141 plays a pivotal role in limb development and may function as a transcriptional repressor. Its involvement in the intricate processes of gene expression regulation underscores its importance in cellular mechanisms.
Therapeutic significance:
The association of Zinc finger protein 141 with Polydactyly, postaxial A6, highlights its clinical relevance. Understanding the role of Zinc finger protein 141 could open doors to potential therapeutic strategies for limb malformations.