Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q16820
UPID:
MEP1B_HUMAN
Alternative names:
Endopeptidase-2; Meprin B; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta; PABA peptide hydrolase; PPH beta
Alternative UPACC:
Q16820; B7ZM35; B9EGL6; Q670J1
Background:
Meprin A subunit beta, also known as Meprin B, is a membrane metallopeptidase crucial for shedding many membrane-bound proteins. It exhibits a strong preference for acidic amino acids at the P1' position, processing substrates like FGF19, VGFA, and IL1B. This protein plays a significant role in inflammation and tissue remodeling by degrading extracellular matrix components.
Therapeutic significance:
Understanding the role of Meprin A subunit beta could open doors to potential therapeutic strategies, especially in managing inflammation and facilitating tissue repair.