Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q16853
UPID:
AOC3_HUMAN
Alternative names:
Copper amine oxidase; HPAO; Semicarbazide-sensitive amine oxidase; Vascular adhesion protein 1
Alternative UPACC:
Q16853; B2RCI5; K7ESB3; L0L8N9; Q45F94
Background:
Membrane primary amine oxidase, also known as Copper amine oxidase, HPAO, Semicarbazide-sensitive amine oxidase, and Vascular adhesion protein 1, plays a crucial role in cell adhesion, facilitating lymphocyte extravasation and recirculation. This protein's activity includes semicarbazide-sensitive monoamine oxidase functionality, contributing to its involvement in adipogenesis.
Therapeutic significance:
Understanding the role of Membrane primary amine oxidase could open doors to potential therapeutic strategies. Its involvement in lymphocyte function and adipogenesis highlights its potential as a target for therapeutic intervention in immune and metabolic disorders.