Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q3SXY7
UPID:
LRIT3_HUMAN
Alternative names:
-
Alternative UPACC:
Q3SXY7; C9J1C2; Q6ZTG1
Background:
Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 plays a crucial role in the visual system. It facilitates synaptic transmission between cone photoreceptor cells and retinal bipolar cells, essential for processing light-evoked stimuli. This protein is pivotal for the localization of the TRPM1 cation channel in retinal ON-bipolar cells and influences cone synapse formation.
Therapeutic significance:
Linked to congenital stationary night blindness, understanding the function of this protein could pave the way for innovative treatments for visual impairments. Its involvement in synaptic transmission and cone synapse formation highlights its potential as a therapeutic target.