Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q3SY84
UPID:
K2C71_HUMAN
Alternative names:
Cytokeratin-71; Keratin-71; Type II inner root sheath-specific keratin-K6irs1; Type-II keratin Kb34
Alternative UPACC:
Q3SY84; B3KVC1; Q3SY85; Q96DU2
Background:
Keratin, type II cytoskeletal 71, known by alternative names such as Cytokeratin-71, Keratin-71, and Type-II keratin Kb34, plays a pivotal role in hair formation. It is an essential component of keratin intermediate filaments in the inner root sheath of the hair follicle, crucial for maintaining hair structure and integrity.
Therapeutic significance:
Linked to Hypotrichosis 13, a condition marked by sparse hair due to abnormal follicles, understanding the role of Keratin, type II cytoskeletal 71 could open doors to potential therapeutic strategies for hair growth disorders.