Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q587J8
UPID:
KHDC3_HUMAN
Alternative names:
ES cell-associated transcript 1 protein; KHDC3-like protein
Alternative UPACC:
Q587J8; B2RNW7
Background:
KH domain-containing protein 3, also known as ES cell-associated transcript 1 protein or KHDC3-like protein, plays a pivotal role in DNA repair, embryonic cell division, and neural stem cell neurogenesis. It is crucial for the restart of stalled replication forks, homologous recombination-mediated DNA repair, and the maintenance of euploidy during embryogenesis. This protein also regulates actin dynamics, spindle assembly, and neuronal differentiation.
Therapeutic significance:
The association of KH domain-containing protein 3 with Hydatidiform mole, recurrent, 2, a disorder marked by abnormal pregnancies, underscores its potential as a target for therapeutic intervention. Understanding the role of KH domain-containing protein 3 could open doors to potential therapeutic strategies.