Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q5JTW2
UPID:
CEP78_HUMAN
Alternative names:
-
Alternative UPACC:
Q5JTW2; A1A4S8; E9PHX5; Q5BJE3; Q5JTW0; Q5JTW1; Q9H9N3
Background:
Centrosomal protein of 78 kDa (Cep78) is pivotal in cellular processes, notably for its role in centrosome localization and centriole duplication, facilitated by PLK4. It is also implicated in cilium biogenesis, essential for cell signaling and development. The protein's involvement in these critical cellular functions underscores its importance in maintaining cellular integrity and function.
Therapeutic significance:
Cep78's association with Cone-rod dystrophy and hearing loss 1, a disease characterized by progressive vision and hearing loss, highlights its potential as a therapeutic target. Understanding the role of Centrosomal protein of 78 kDa could open doors to potential therapeutic strategies, offering hope for interventions in diseases marked by sensory loss.