Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q5RI15
UPID:
COX20_HUMAN
Alternative names:
-
Alternative UPACC:
Q5RI15; Q8WV86
Background:
Cytochrome c oxidase assembly protein COX20, mitochondrial, is pivotal for the assembly of mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. It functions as a chaperone during the early stages of cytochrome c oxidase subunit II maturation, facilitating the integration of the mature subunit into the CIV holoenzyme.
Therapeutic significance:
The protein is linked to Mitochondrial complex IV deficiency, nuclear type 11, a disorder marked by cerebellar ataxia, dystonia, and increased serum lactate levels. Understanding the role of Cytochrome c oxidase assembly protein COX20 could open doors to potential therapeutic strategies for this mitochondrial disorder.