Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q5T0N1
UPID:
CFA70_HUMAN
Alternative names:
Tetratricopeptide repeat protein 18
Alternative UPACC:
Q5T0N1; C9JIZ9; Q5T0M4; Q5T0M9; Q5T0N0; Q69YH9; Q8IYZ8; Q8N7D5; Q8NI30; Q8NI31
Background:
Cilia- and flagella-associated protein 70, also known as Tetratricopeptide repeat protein 18, is a crucial axoneme-binding protein. It plays a significant role in regulating ciliary motility and maintaining cilium length, essential for cellular functions and signaling.
Therapeutic significance:
Linked to Spermatogenic failure 41, a disorder characterized by severe asthenozoospermia and flagellar abnormalities, this protein's dysfunction underscores its importance in fertility. Understanding the role of Cilia- and flagella-associated protein 70 could open doors to potential therapeutic strategies for treating infertility.