Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q5T655
UPID:
CFA58_HUMAN
Alternative names:
Coiled-coil domain-containing protein 147
Alternative UPACC:
Q5T655; D3DRA6; Q8NA27
Background:
Cilia- and flagella-associated protein 58, also known as Coiled-coil domain-containing protein 147, plays a pivotal role in sperm flagellar axoneme assembly and organization. This protein is crucial for the elongation of the primary cilium and the sperm flagellar midpiece, modulating the Notch signaling pathway to ensure proper cellular function and development.
Therapeutic significance:
Linked to Spermatogenic failure 49, a disorder marked by asthenoteratozoospermia and abnormal sperm flagella, understanding the role of Cilia- and flagella-associated protein 58 could open doors to potential therapeutic strategies. Targeting this protein's pathway may offer new avenues for treating infertility related to flagellar defects.