Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q5T848
UPID:
MGLYR_HUMAN
Alternative names:
G-protein coupled receptor 158
Alternative UPACC:
Q5T848; Q6QR81; Q9ULT3
Background:
The Metabotropic glycine receptor, also known as G-protein coupled receptor 158, is a key player in brain function, particularly in synapse formation and regulation. It operates uniquely by recruiting the RGS7-GNB5 complex, diverging from typical G-protein activation. This receptor's interaction with glycine or taurine shifts its intracellular conformation, influencing cAMP levels and thus, neuronal excitability and synaptic transmission. Its role extends to mood and cognition regulation, spatial learning, and synaptic organization in the hippocampus.
Therapeutic significance:
Understanding the role of Metabotropic glycine receptor could open doors to potential therapeutic strategies.