Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q5TD94
UPID:
RSH4A_HUMAN
Alternative names:
Radial spoke head-like protein 3
Alternative UPACC:
Q5TD94; B4DSI1; Q3KP24; Q5TD95
Background:
Radial spoke head protein 4 homolog A, also known as Radial spoke head-like protein 3, plays a crucial role in ciliary motility by being a component of the axonemal radial spoke head. Its involvement is essential for the assembly of triplet radial spokes head in motile cilia, highlighting its significance in cellular movement and fluid flow across cell surfaces.
Therapeutic significance:
The protein is directly linked to Primary ciliary dyskinesia, 11, a disorder marked by motile cilia abnormalities leading to severe respiratory infections and reduced fertility. Understanding the role of Radial spoke head protein 4 homolog A could open doors to potential therapeutic strategies for treating this condition.