Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q66GS9
UPID:
CP135_HUMAN
Alternative names:
Centrosomal protein 4
Alternative UPACC:
Q66GS9; B2RMY0; O75130; Q58F25; Q9H8H7
Background:
Centrosomal protein of 135 kDa, also known as Centrosomal protein 4, plays a pivotal role in centriole biogenesis. It functions as a scaffolding protein, essential for the recruitment of centriole satellite proteins and centriole-centriole cohesion during interphase. Its involvement in the targeting of proteins such as PCM1, SSX2IP, CEP290, and the recruitment of WRAP73 and CEP295 to centrioles underscores its critical role in cell division.
Therapeutic significance:
The protein's link to Microcephaly 8, a condition characterized by significantly reduced brain size and mental retardation, highlights its potential as a target for therapeutic intervention. Understanding the role of Centrosomal protein of 135 kDa could open doors to potential therapeutic strategies.