Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q6DJT9
UPID:
PLAG1_HUMAN
Alternative names:
Pleiomorphic adenoma gene 1 protein
Alternative UPACC:
Q6DJT9; B4DLC2; Q59GH8; Q9Y4L2
Background:
Zinc finger protein PLAG1, also known as Pleiomorphic adenoma gene 1 protein, plays a pivotal role in cell proliferation and development. It functions as a transcription factor, activating target genes like IGFII, which leads to uncontrolled cell growth. Its overexpression is linked to various tumors, including pleomorphic adenomas of the salivary gland and hepatoblastoma, a common liver tumor in children.
Therapeutic significance:
Given its role in diseases like Silver-Russell syndrome 4 and its association with tumor development, targeting PLAG1 could offer new avenues for therapeutic interventions. Understanding the role of Zinc finger protein PLAG1 could open doors to potential therapeutic strategies.