Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q6P1N9
UPID:
TATD1_HUMAN
Alternative names:
Hepatocarcinoma high expression protein
Alternative UPACC:
Q6P1N9; B2R5J0; Q8TD02; Q9BY40
Background:
Deoxyribonuclease TATDN1, also known as Hepatocarcinoma high expression protein, plays a pivotal role in DNA processing. It catalyzes the decatenation of kinetoplast DNA, transforming circular DNA molecules into linear forms. This activity is crucial for chromosomal segregation and cell cycle progression, especially during eye development, suggesting its fundamental role in cellular biology.
Therapeutic significance:
Understanding the role of Deoxyribonuclease TATDN1 could open doors to potential therapeutic strategies. Its involvement in key biological processes such as DNA decatenation and chromosomal segregation highlights its potential as a target for therapeutic intervention in diseases where these processes are dysregulated.