Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q6P6C2
UPID:
ALKB5_HUMAN
Alternative names:
Alkylated DNA repair protein alkB homolog 5; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5
Alternative UPACC:
Q6P6C2; B4DVJ4; D3DXC6; Q9NXD6
Background:
RNA demethylase ALKBH5, also known as Alkylated DNA repair protein alkB homolog 5, plays a crucial role in the post-transcriptional modification of RNA. It specifically targets N(6)-methyladenosine (m6A) RNA, the most common internal modification in eukaryotic messenger RNA (mRNA), facilitating its oxidative demethylation. This process is vital for mRNA processing and export, impacting gene expression. ALKBH5's activity is dependent on molecular oxygen, alpha-ketoglutarate, and iron, showcasing its biochemical complexity.
Therapeutic significance:
Understanding the role of RNA demethylase ALKBH5 could open doors to potential therapeutic strategies. Its involvement in mRNA processing and gene expression regulation highlights its potential as a target for modulating disease-related gene expression patterns.