Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q6P9F0
UPID:
CCD62_HUMAN
Alternative names:
Protein TSP-NY; Protein aaa
Alternative UPACC:
Q6P9F0; A8K8V1; B3KUP3; Q6ZVF2; Q86VJ0; Q9BYZ5
Background:
Coiled-coil domain-containing protein 62, also known as Protein TSP-NY and Protein aaa, plays a pivotal role in spermiogenesis, particularly in acrosome formation. This protein acts as a nuclear receptor coactivator, enhancing the transactivation of estrogen receptors ESR1 and ESR2, and to a lesser extent, modulates progesterone, glucocorticoid, and androgen receptors. Its involvement in hormone receptor signaling underscores its importance in reproductive biology.
Therapeutic significance:
Linked to Spermatogenic failure 67, a disorder leading to male infertility due to globozoospermia, understanding the role of Coiled-coil domain-containing protein 62 could open doors to potential therapeutic strategies. Its critical function in acrosome formation and hormone receptor modulation makes it a promising target for addressing infertility issues.