Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q6QHK4
UPID:
FIGLA_HUMAN
Alternative names:
Class C basic helix-loop-helix protein 8; Folliculogenesis-specific basic helix-loop-helix protein; Transcription factor FIGa
Alternative UPACC:
Q6QHK4
Background:
Factor in the germline alpha (FIGLA) is a pivotal transcription factor in oocyte-specific gene expression, crucial for folliculogenesis and early embryonic survival. It regulates the expression of zona pellucida genes (ZP1, ZP2, ZP3), essential for fertilization. FIGLA's role extends to maintaining oocytes and forming primordial follicles, with its presence in adult females indicating additional regulatory pathways for normal ovarian development.
Therapeutic significance:
Premature ovarian failure 6, a condition marked by early cessation of ovarian function, is linked to mutations affecting FIGLA. Understanding FIGLA's role could unveil new therapeutic strategies for treating ovarian disorders.