Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q6ZWH5
UPID:
NEK10_HUMAN
Alternative names:
Never in mitosis A-related kinase 10
Alternative UPACC:
Q6ZWH5; A8MWG1; B9ZVR0; Q45VJ4; Q6ZR11; Q7Z671; Q86XB1; Q96MB3
Background:
Serine/threonine-protein kinase Nek10, also known as Never in mitosis A-related kinase 10, plays a crucial role in the cellular response to UV irradiation. It is pivotal in mediating G2/M cell cycle arrest, MEK autoactivation, and the activation of the ERK1/2-signaling pathway following UV exposure. Additionally, in the ciliated cells of airways, Nek10 regulates mucociliary transport, essential for respiratory health.
Therapeutic significance:
Nek10's involvement in primary ciliary dyskinesia, specifically Ciliary dyskinesia, primary, 44, underscores its therapeutic potential. This autosomal recessive disease, characterized by motile cilia abnormalities leading to chronic respiratory infections, highlights the importance of Nek10 in respiratory health. Understanding the role of Serine/threonine-protein kinase Nek10 could open doors to potential therapeutic strategies for respiratory diseases.