Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q7L2J0
UPID:
MEPCE_HUMAN
Alternative names:
Bicoid-interacting protein 3 homolog
Alternative UPACC:
Q7L2J0; B3KP86; D6W5V7; Q9NPD4
Background:
The 7SK snRNA methylphosphate capping enzyme, also known as Bicoid-interacting protein 3 homolog, plays a pivotal role in RNA metabolism. It functions as an S-adenosyl-L-methionine-dependent methyltransferase, adding a methylphosphate cap to the 5'-end of 7SK snRNA, which stabilizes the RNA molecule. Beyond its enzymatic role, it is integral to the 7SK RNP complex, regulating transcription elongation by sequestering the positive transcription elongation factor b (P-TEFb) and promoting snRNA gene transcription via interaction with the little elongation complex (LEC).
Therapeutic significance:
Understanding the role of 7SK snRNA methylphosphate capping enzyme could open doors to potential therapeutic strategies.