AI-ACCELERATED DRUG DISCOVERY
Available from Reaxense
This protein is integrated into the Receptor.AI ecosystem as a prospective target with high therapeutic potential. We performed a comprehensive characterization of COP9 signalosome complex subunit 6 including:
1. LLM-powered literature research
Our custom-tailored LLM extracted and formalized all relevant information about the protein from a large set of structured and unstructured data sources and stored it in the form of a Knowledge Graph. This comprehensive analysis allowed us to gain insight into COP9 signalosome complex subunit 6 therapeutic significance, existing small molecule ligands, relevant off-targets, and protein-protein interactions.
Fig. 1. Preliminary target research workflow
2. AI-Driven Conformational Ensemble Generation
Starting from the initial protein structure, we employed advanced AI algorithms to predict alternative functional states of COP9 signalosome complex subunit 6, including large-scale conformational changes along "soft" collective coordinates. Through molecular simulations with AI-enhanced sampling and trajectory clustering, we explored the broad conformational space of the protein and identified its representative structures. Utilizing diffusion-based AI models and active learning AutoML, we generated a statistically robust ensemble of equilibrium protein conformations that capture the receptor's full dynamic behavior, providing a robust foundation for accurate structure-based drug design.
Fig. 2. AI-powered molecular dynamics simulations workflow
3. Binding pockets identification and characterization
We employed the AI-based pocket prediction module to discover orthosteric, allosteric, hidden, and cryptic binding pockets on the protein’s surface. Our technique integrates the LLM-driven literature search and structure-aware ensemble-based pocket detection algorithm that utilizes previously established protein dynamics. Tentative pockets are then subject to AI scoring and ranking with simultaneous detection of false positives. In the final step, the AI model assesses the druggability of each pocket enabling a comprehensive selection of the most promising pockets for further targeting.
Fig. 3. AI-based binding pocket detection workflow
4. AI-Powered Virtual Screening
Our ecosystem is equipped to perform AI-driven virtual screening on COP9 signalosome complex subunit 6. With access to a vast chemical space and cutting-edge AI docking algorithms, we can rapidly and reliably predict the most promising, novel, diverse, potent, and safe small molecule ligands of COP9 signalosome complex subunit 6. This approach allows us to achieve an excellent hit rate and to identify compounds ready for advanced lead discovery and optimization.
Fig. 4. The screening workflow of Receptor.AI
Receptor.AI, in partnership with Reaxense, developed a next-generation technology for on-demand focused library design to enable extensive target exploration.
The focused library for COP9 signalosome complex subunit 6 includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
COP9 signalosome complex subunit 6
partner:
Reaxense
upacc:
Q7L5N1
UPID:
CSN6_HUMAN
Alternative names:
JAB1-containing signalosome subunit 6; MOV34 homolog; Vpr-interacting protein
Alternative UPACC:
Q7L5N1; A4D2A3; O15387
Background:
COP9 signalosome complex subunit 6 (CSN6), also known as JAB1-containing signalosome subunit 6, MOV34 homolog, and Vpr-interacting protein, plays a pivotal role in cellular and developmental processes. It is a crucial component of the COP9 signalosome complex (CSN), regulating the ubiquitin conjugation pathway by deneddylation of cullin subunits of SCF-type E3 ligase complexes. This action decreases the ubiquitin ligase activity of complexes like SCF, CSA, or DDB2. CSN6 is involved in the phosphorylation of key proteins such as p53/TP53, c-jun/JUN, and others, potentially through its association with CK2 and PKD kinases. It also exhibits glucocorticoid receptor-responsive activity and stabilizes COP1, influencing the ubiquitination of COP1 targets.
Therapeutic significance:
Understanding the role of COP9 signalosome complex subunit 6 could open doors to potential therapeutic strategies.
