Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q7Z3K3
UPID:
POGZ_HUMAN
Alternative names:
Suppressor of hairy wing homolog 5; Zinc finger protein 280E; Zinc finger protein 635
Alternative UPACC:
Q7Z3K3; B4DTP8; B4DYL9; B7ZBY5; E9PM80; O75049; Q3LIC4; Q5SZS1; Q5SZS2; Q5SZS3; Q5SZS4; Q8TDZ7; Q9Y4X7
Background:
The Pogo transposable element with ZNF domain, also known as Suppressor of hairy wing homolog 5, Zinc finger protein 280E, and Zinc finger protein 635, is pivotal in mitotic cell cycle progression. It plays a crucial role in kinetochore assembly, sister chromatid cohesion, and DNA double-strand break repair through homologous recombination, influencing chromosome segregation and genomic stability.
Therapeutic significance:
Linked to White-Sutton syndrome, characterized by developmental delay and intellectual disability, this protein's genetic variants highlight its clinical relevance. Understanding its role could unveil novel therapeutic strategies for managing this syndrome and related chromosomal disorders.