Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q7Z3T8
UPID:
ZFY16_HUMAN
Alternative names:
Endofin; Endosome-associated FYVE domain protein
Alternative UPACC:
Q7Z3T8; O15023; Q5H9U2; Q7LAU7; Q86T69; Q8N5L3; Q8NEK3
Background:
Zinc finger FYVE domain-containing protein 16, also known as Endofin and Endosome-associated FYVE domain protein, plays a crucial role in regulating membrane trafficking within the endosomal pathway. Its overexpression leads to endosome aggregation, highlighting its importance in cellular trafficking processes. Additionally, it is essential for targeting TOM1 to endosomes, indicating its pivotal role in cellular sorting mechanisms.
Therapeutic significance:
Understanding the role of Zinc finger FYVE domain-containing protein 16 could open doors to potential therapeutic strategies. Its involvement in membrane trafficking and endosomal pathway regulation presents a unique opportunity for targeting diseases where these processes are disrupted.