Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q7Z5L9
UPID:
I2BP2_HUMAN
Alternative names:
-
Alternative UPACC:
Q7Z5L9; B1AM35; B1AM36; Q6P083; Q7Z5L8; Q8N351; Q8WUH8
Background:
Interferon regulatory factor 2-binding protein 2 plays a pivotal role in various cellular processes, including acting as a transcriptional corepressor and coactivator in specific contexts. It is involved in repressing the NFAT1-dependent transactivation and in the differentiation of immature B-cells, highlighting its multifaceted role in immune regulation and cellular differentiation.
Therapeutic significance:
Linked to Immunodeficiency, common variable, 14 (CVID14), a condition characterized by recurrent infections and hypogammaglobulinemia, this protein's genetic variants underscore its clinical relevance. Understanding the role of Interferon regulatory factor 2-binding protein 2 could open doors to potential therapeutic strategies for managing immunodeficiencies.