Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q7Z6V5
UPID:
ADAT2_HUMAN
Alternative names:
Deaminase domain-containing protein 1; tRNA-specific adenosine-34 deaminase subunit ADAT2
Alternative UPACC:
Q7Z6V5; A6NL12; B3KWY3; Q7Z327; Q8IY39
Background:
tRNA-specific adenosine deaminase 2, also known as Deaminase domain-containing protein 1 or ADAT2, plays a crucial role in the modification of adenosine-34 to inosine in tRNAs. This enzymatic activity is vital for the proper decoding of genetic information during protein synthesis.
Therapeutic significance:
Understanding the role of tRNA-specific adenosine deaminase 2 could open doors to potential therapeutic strategies. Its pivotal function in protein synthesis underscores its importance in cellular biology and disease mechanisms.