Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q86SG3
UPID:
DAZ4_HUMAN
Alternative names:
-
Alternative UPACC:
Q86SG3; Q9NR88; Q9NR89
Background:
Deleted in azoospermia protein 4 (DAZ4) plays a pivotal role in male fertility, acting as an RNA-binding protein essential for spermatogenesis. It functions by potentially binding to the 3'-UTR of mRNAs, regulating their translation and ensuring proper sperm development.
Therapeutic significance:
DAZ4's involvement in Spermatogenic failure Y-linked 2, characterized by reduced or absent sperm, highlights its critical role in male infertility. Understanding the role of Deleted in azoospermia protein 4 could open doors to potential therapeutic strategies for treating infertility.