Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q86SU0
UPID:
ILDR1_HUMAN
Alternative names:
Angulin-2
Alternative UPACC:
Q86SU0; Q6ZP61; Q7Z578
Background:
Immunoglobulin-like domain-containing receptor 1, also known as Angulin-2, plays a pivotal role in maintaining epithelial barrier function. It ensures the integrity of tricellular tight junctions crucial for auditory neurosensory health and mediates essential processes in the small intestine. Additionally, it influences influenza virus infection dynamics.
Therapeutic significance:
Given its critical function in preserving hearing by maintaining tricellular tight junctions, Immunoglobulin-like domain-containing receptor 1 is linked to Deafness, autosomal recessive, 42. Understanding its role could lead to novel treatments for sensorineural hearing loss.