Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q86WG3
UPID:
ATCAY_HUMAN
Alternative names:
Ataxia cayman type protein; BNIP-2-homology
Alternative UPACC:
Q86WG3; Q8NAQ2; Q8TAQ3; Q96HC6; Q96JF5
Background:
Caytaxin, also known as Ataxia Cayman type protein, plays a crucial role in the development of neural tissues, especially in the postnatal maturation of the cerebellar cortex. It is implicated in neurotransmission regulation through its potential influence on glutaminase/GLS, an enzyme vital for glutamate neurotransmitter production in neurons. Additionally, Caytaxin may affect the positioning of mitochondria within axons and dendrites.
Therapeutic significance:
Caytaxin's mutation is directly linked to Cerebellar ataxia, Cayman type, characterized by psychomotor retardation and cerebellar dysfunction. Understanding the role of Caytaxin could open doors to potential therapeutic strategies for this condition.