Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q86X45
UPID:
DAA11_HUMAN
Alternative names:
Leucine-rich repeat-containing protein 6; Leucine-rich testis-specific protein; Protein tilB homolog; Testis-specific leucine-rich repeat protein
Alternative UPACC:
Q86X45; Q13648; Q4G183
Background:
Dynein axonemal assembly factor 11, also known as Leucine-rich repeat-containing protein 6, plays a pivotal role in dynein arm assembly, crucial for cilia and spermatozoal flagella motility. It ensures the transport of outer dynein arm proteins to cilia, facilitating respiratory function and male fertility.
Therapeutic significance:
Its association with Primary Ciliary Dyskinesia, particularly Ciliary dyskinesia, primary, 19, underscores its therapeutic potential. Understanding the role of Dynein axonemal assembly factor 11 could open doors to potential therapeutic strategies for treating respiratory and fertility-related disorders.