Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8IU68
UPID:
TMC8_HUMAN
Alternative names:
Epidermodysplasia verruciformis protein 2
Alternative UPACC:
Q8IU68; Q2YDC0; Q8IWU7; Q8N358; Q8NF04
Background:
Transmembrane channel-like protein 8, also known as Epidermodysplasia verruciformis protein 2, plays a crucial role as a probable ion channel. This protein is pivotal in cellular processes, facilitating the transport of ions across the cell membrane, which is essential for maintaining cellular homeostasis and signaling.
Therapeutic significance:
Linked to Epidermodysplasia verruciformis 2, a condition marked by a heightened susceptibility to specific human papillomaviruses and a significant risk of skin carcinoma, Transmembrane channel-like protein 8's study is vital. Understanding its role could unveil new therapeutic strategies for managing this genodermatosis and preventing skin cancer development.