Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8IVV2
UPID:
LOXH1_HUMAN
Alternative names:
-
Alternative UPACC:
Q8IVV2; B7WNN3; B7WNT1; B7WPI9; H7BZ41; Q6ZRY7; Q86WW9; Q96DL7
Background:
Lipoxygenase homology domain-containing protein 1 plays a pivotal role in auditory processes, essential for the normal functioning of hair cells in the inner ear. This protein's involvement is crucial for maintaining the integrity of auditory mechanisms, facilitating sound wave transduction into neural signals.
Therapeutic significance:
Deafness, autosomal recessive, 77, a condition marked by progressive hearing loss, is directly linked to mutations in the gene encoding this protein. Understanding the role of Lipoxygenase homology domain-containing protein 1 could open doors to potential therapeutic strategies, offering hope for individuals affected by this form of hearing impairment.