Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q8IX21
UPID:
SLF2_HUMAN
Alternative names:
Smc5/6 localization factor 1
Alternative UPACC:
Q8IX21; A8K950; B1AL17; Q5W0L8; Q6GMU6; Q9NPE8
Background:
The SMC5-SMC6 complex localization factor protein 2, also known as Smc5/6 localization factor 1, is pivotal in the DNA damage response (DDR) pathway. It regulates postreplication repair of UV-damaged DNA and maintains genomic stability. This protein, through the SLF1-SLF2 complex, links RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links and DNA double-strand breaks sites during DNA repair.
Therapeutic significance:
Given its crucial role in DNA repair and genomic stability, understanding the role of SMC5-SMC6 complex localization factor protein 2 could open doors to potential therapeutic strategies for Atelis syndrome 1, a disorder marked by developmental delay, microcephaly, and various physical anomalies, where patient cells exhibit spontaneous chromosome breakage.