Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8IXL6
UPID:
FA20C_HUMAN
Alternative names:
Dentin matrix protein 4; Golgi casein kinase; Golgi-enriched fraction casein kinase
Alternative UPACC:
Q8IXL6; A4D2Q5; L8B5W8; Q5I0W9; Q7Z4I0; Q9NPT2
Background:
Extracellular serine/threonine protein kinase FAM20C, also known as Dentin matrix protein 4, Golgi casein kinase, and Golgi-enriched fraction casein kinase, is pivotal in biomineralization of bones and teeth. It phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs, contributing to the extracellular phosphoproteome. FAM20C's activity enhances ERO1A, crucial for endoplasmic reticulum redox homeostasis and oxidative protein folding. It also plays a role in osteoblast differentiation and mineralization.
Therapeutic significance:
Raine syndrome, an osteosclerotic bone dysplasia with neonatal lethal outcomes, is linked to variants affecting FAM20C. Understanding the role of Extracellular serine/threonine protein kinase FAM20C could open doors to potential therapeutic strategies for this and related disorders.