Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8IYB8
UPID:
SUV3_HUMAN
Alternative names:
Suppressor of var1 3-like protein 1
Alternative UPACC:
Q8IYB8; A8K301; O43630
Background:
ATP-dependent RNA helicase SUPV3L1, mitochondrial, also known as Suppressor of var1 3-like protein 1, is a pivotal enzyme in mitochondrial RNA metabolism. It forms part of the mitochondrial degradosome complex, crucial for degrading double-stranded RNA in an ATP-dependent manner. This protein unwinds both DNA and RNA duplexes, playing a key role in mitochondrial RNA surveillance, stability of mRNAs, and chromatin maintenance. Its ability to prevent apoptosis underscores its importance in cellular survival.
Therapeutic significance:
Understanding the role of ATP-dependent RNA helicase SUPV3L1, mitochondrial could open doors to potential therapeutic strategies.