Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8N0Z6
UPID:
TTC5_HUMAN
Alternative names:
Stress-responsive activator of p300
Alternative UPACC:
Q8N0Z6; A8MQ18; Q96HF9
Background:
Tetratricopeptide repeat protein 5 (TTC5), also known as Stress-responsive activator of p300, plays a pivotal role in cellular mechanisms including actin regulation, autophagy, chromatin regulation, and DNA repair. It interacts with various cofactors and proteins to modulate cellular responses to stress, nutrient availability, and DNA damage, thereby influencing cell survival, apoptosis, and mitochondrial function.
Therapeutic significance:
Given its involvement in neurodevelopmental disorder with cerebral atrophy and variable facial dysmorphism, understanding the role of TTC5 could open doors to potential therapeutic strategies for treating this genetic condition.