Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8N100
UPID:
ATOH7_HUMAN
Alternative names:
Atonal bHLH transcription factor 7; Class A basic helix-loop-helix protein 13; Protein atonal homolog 7
Alternative UPACC:
Q8N100
Background:
Transcription factor ATOH7, known as Atonal bHLH transcription factor 7, plays a pivotal role in the development of the retina by regulating a transcriptional program of retinal ganglion cell determinant genes. Its binding to DNA at the consensus sequence 5'-CAG[GC]TG-3' and potential dimerization with TCF3 isoform E47 underscores its significance in photoreceptor population development and retinal circadian rhythm photoentrainment.
Therapeutic significance:
The association of ATOH7 with Persistent hyperplastic primary vitreous, an autosomal recessive eye malformation, highlights its therapeutic significance. Understanding the role of ATOH7 could open doors to potential therapeutic strategies for eye diseases characterized by retinal detachment and lens opacity.