Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8N126
UPID:
CADM3_HUMAN
Alternative names:
Brain immunoglobulin receptor; Immunoglobulin superfamily member 4B; Nectin-like protein 1; Synaptic cell adhesion molecule 3; TSLC1-like protein 1
Alternative UPACC:
Q8N126; Q8IZQ9; Q9NVJ5; Q9UJP1
Background:
Cell adhesion molecule 3, also known as Brain immunoglobulin receptor, Immunoglobulin superfamily member 4B, Nectin-like protein 1, Synaptic cell adhesion molecule 3, and TSLC1-like protein 1, plays a crucial role in cell-cell adhesion. It exhibits both calcium-independent homophilic and heterophilic cell-cell adhesion activities, interacting with various proteins such as IGSF4, NECTIN1, and NECTIN3. Its association with EPB41L1 suggests a regulatory function in cell junctions.
Therapeutic significance:
Linked to Charcot-Marie-Tooth disease, axonal, 2FF, a peripheral nervous system disorder characterized by muscle weakness and atrophy, Cell adhesion molecule 3's genetic variants highlight its therapeutic potential. Understanding its role could pave the way for innovative treatments for this and similar neuropathies.