Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8N1G0
UPID:
ZN687_HUMAN
Alternative names:
-
Alternative UPACC:
Q8N1G0; D3DV17; Q68DQ8; Q9H937; Q9P2A7
Background:
Zinc finger protein 687, encoded by the gene with accession number Q8N1G0, plays a crucial role in the cellular machinery, potentially involved in transcriptional regulation. Its unique structure, characterized by zinc finger motifs, suggests a specific interaction with DNA, guiding the expression of genes critical for cellular function.
Therapeutic significance:
The protein's association with Paget disease of bone 6, a condition marked by abnormal bone remodeling and susceptibility to fractures, underscores its clinical importance. Understanding the role of Zinc finger protein 687 could open doors to potential therapeutic strategies, especially considering its link to osteosarcoma in disease progression.