Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8NCM2
UPID:
KCNH5_HUMAN
Alternative names:
Ether-a-go-go potassium channel 2; Voltage-gated potassium channel subunit Kv10.2
Alternative UPACC:
Q8NCM2; C9JP98
Background:
Potassium voltage-gated channel subfamily H member 5, also known as Ether-a-go-go potassium channel 2 and Voltage-gated potassium channel subunit Kv10.2, plays a crucial role in cellular electrophysiology. This protein forms a pore for potassium ions, facilitating an outward rectifying current that is essential for the electrical activity of cells. Its activity can be influenced by cAMP levels and the assembly of subunits, indicating a complex regulation mechanism.
Therapeutic significance:
Understanding the role of Potassium voltage-gated channel subfamily H member 5 could open doors to potential therapeutic strategies. Its pivotal function in modulating cellular electrical activity makes it a promising target for drug discovery, aiming to treat diseases associated with electrical dysregulation.