Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8NE71
UPID:
ABCF1_HUMAN
Alternative names:
ATP-binding cassette 50; TNF-alpha-stimulated ABC protein
Alternative UPACC:
Q8NE71; A2BF75; O14897; Q69YP6
Background:
ATP-binding cassette sub-family F member 1, also known as ATP-binding cassette 50 and TNF-alpha-stimulated ABC protein, plays a crucial role in mRNA translation initiation. Specifically, Isoform 2 of this protein is essential for efficient Cap- and IRES-mediated mRNA translation initiation, although it does not participate in ribosome biogenesis.
Therapeutic significance:
Understanding the role of ATP-binding cassette sub-family F member 1 could open doors to potential therapeutic strategies. Its involvement in mRNA translation initiation suggests its potential impact on protein synthesis, offering a promising avenue for research into diseases where protein synthesis regulation is disrupted.