Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8NEN0
UPID:
ARMC2_HUMAN
Alternative names:
-
Alternative UPACC:
Q8NEN0; A8K8Y4; B4DGF5; G5E993; Q5VVY8; Q9H0K9
Background:
Armadillo repeat-containing protein 2 plays a crucial role in sperm flagellum axoneme organization, essential for proper sperm motility and morphology. By facilitating axonemal central pair complex assembly and stability, it ensures the structural integrity necessary for sperm function.
Therapeutic significance:
Linked to Spermatogenic failure 38, a disorder marked by asthenoteratozoospermia, where sperm exhibit multiple morphological abnormalities. Understanding the role of Armadillo repeat-containing protein 2 could open doors to potential therapeutic strategies for treating infertility.