Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8WVN8
UPID:
UB2Q2_HUMAN
Alternative names:
E2 ubiquitin-conjugating enzyme Q2; Ubiquitin carrier protein Q2; Ubiquitin-protein ligase Q2
Alternative UPACC:
Q8WVN8; B7Z3Q2; H3BRG2; Q8N4G6; Q96J08
Background:
Ubiquitin-conjugating enzyme E2 Q2, also known as E2 ubiquitin-conjugating enzyme Q2, Ubiquitin carrier protein Q2, and Ubiquitin-protein ligase Q2, plays a pivotal role in protein ubiquitination. It accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins, specifically mediating 'Lys-48'-linked polyubiquitination. This process is crucial for protein degradation, signaling, and cell cycle regulation.
Therapeutic significance:
Understanding the role of Ubiquitin-conjugating enzyme E2 Q2 could open doors to potential therapeutic strategies. Its involvement in protein ubiquitination highlights its importance in cellular processes and disease mechanisms.