Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q8WW35
UPID:
DYT2B_HUMAN
Alternative names:
Tctex1 domain-containing protein 2
Alternative UPACC:
Q8WW35; A6NCN5
Background:
Dynein light chain Tctex-type protein 2B, also known as Tctex1 domain-containing protein 2, plays a crucial role in the cytoplasmic dynein 2 complex. This complex is essential for the movement of cargos along microtubules within cilia and flagella, working in harmony with the intraflagellar transport system. It is specifically required for proper retrograde ciliary transport, highlighting its significance in cellular functionality and structure.
Therapeutic significance:
The protein's involvement in Short-rib thoracic dysplasia 17 with or without polydactyly, a condition characterized by a range of skeletal and organ anomalies, underscores its potential as a target for therapeutic intervention. Understanding the role of Dynein light chain Tctex-type protein 2B could open doors to potential therapeutic strategies, offering hope for conditions associated with ciliopathies.