Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8WXI2
UPID:
CNKR2_HUMAN
Alternative names:
CNK homolog protein 2
Alternative UPACC:
Q8WXI2; B4DGR4; B7ZLJ1; B9EG83; E7ESA4; O94976; Q5JPK4; Q5JPN0; Q8WXI1
Background:
Connector enhancer of kinase suppressor of ras 2, also known as CNK homolog protein 2, plays a pivotal role in cellular signaling. It is believed to act as an adapter protein or regulator within Ras signaling pathways, which are crucial for cell growth, differentiation, and survival.
Therapeutic significance:
The protein is linked to Intellectual developmental disorder, X-linked, syndromic, Houge type, characterized by developmental delays, intellectual disability, and early-onset seizures. Understanding the role of Connector enhancer of kinase suppressor of ras 2 could open doors to potential therapeutic strategies for this disorder.