Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8WYH8
UPID:
ING5_HUMAN
Alternative names:
p28ING5
Alternative UPACC:
Q8WYH8; A8K1P3; Q53NU6; Q57Z54; Q9BS30
Background:
Inhibitor of growth protein 5, known as p28ING5, plays a crucial role in cellular processes through its involvement in the HBO1 complex and the MOZ/MORF complex. It mediates specific acetylation of histones H3 and H4, influencing chromatin structure and thereby regulating DNA replication and transcriptional coactivation. Additionally, p28ING5 has been shown to inhibit cell growth, delay S-phase progression, and enhance Fas-induced apoptosis, highlighting its potential impact on cell cycle regulation and apoptosis.
Therapeutic significance:
Understanding the role of Inhibitor of growth protein 5 could open doors to potential therapeutic strategies. Its involvement in critical cellular processes such as DNA replication, transcriptional coactivation, and apoptosis regulation underscores its potential as a target for therapeutic intervention in diseases where these processes are dysregulated.