Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q92796
UPID:
DLG3_HUMAN
Alternative names:
Neuroendocrine-DLG; Synapse-associated protein 102; XLMR
Alternative UPACC:
Q92796; B4E0H1; D3DVU5; Q5JUW6; Q5JUW7; Q9ULI8
Background:
Disks large homolog 3, also known as Neuroendocrine-DLG, Synapse-associated protein 102, and XLMR, plays a crucial role in synaptic plasticity following NMDA receptor signaling. This protein is essential for learning, indicating its significant function in the nervous system.
Therapeutic significance:
The protein is linked to Intellectual developmental disorder, X-linked 90, a condition marked by below-average intellectual functioning and impairments in adaptive behavior. Understanding the role of Disks large homolog 3 could open doors to potential therapeutic strategies for this disorder.