Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q92834
UPID:
RPGR_HUMAN
Alternative names:
-
Alternative UPACC:
Q92834; B1ARN3; E9PE28; O00702; O00737; Q3KN84; Q8N5T6; Q93039; Q9HD29; Q9UMR1
Background:
The X-linked retinitis pigmentosa GTPase regulator plays a pivotal role in ciliogenesis, photoreceptor integrity, and possibly in spermatogenesis and intraflagellar transport processes. Its function as a guanine-nucleotide releasing factor and in regulating actin stress filaments and cell contractility underscores its importance in cellular structure and movement.
Therapeutic significance:
Given its critical involvement in a spectrum of retinal dystrophies, including Retinitis pigmentosa 3, X-linked retinitis pigmentosa with sinorespiratory infections, Cone-rod dystrophy X-linked 1, and X-linked atrophic macular degeneration, targeting the X-linked retinitis pigmentosa GTPase regulator offers a promising avenue for therapeutic intervention in these debilitating visual impairments.