Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q92922
UPID:
SMRC1_HUMAN
Alternative names:
BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1
Alternative UPACC:
Q92922; Q17RS0; Q6P172; Q8IWH2
Background:
SWI/SNF complex subunit SMARCC1, also known as BRG1-associated factor 155, plays a pivotal role in chromatin remodeling. It is a part of the SWI/SNF chromatin remodeling complexes, altering DNA-nucleosome topology to activate or repress gene expression. This protein is crucial for the transition of neural progenitors into neurons, highlighting its importance in neural development.
Therapeutic significance:
SWI/SNF complex subunit SMARCC1 is linked to Hydrocephalus, congenital, 5, a condition marked by enlarged ventricles due to cerebrospinal fluid accumulation. Understanding the role of SWI/SNF complex subunit SMARCC1 could open doors to potential therapeutic strategies for this and related neurodevelopmental disorders.