Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q969T7
UPID:
5NT3B_HUMAN
Alternative names:
Cytosolic 5'-nucleotidase 3B; Cytosolic 5'-nucleotidase III-like protein; N(7)-methylguanylate 5'-phosphatase
Alternative UPACC:
Q969T7; A8MWB9; C9JKC4; Q7L3B7
Background:
The 7-methylguanosine phosphate-specific 5'-nucleotidase, known alternatively as Cytosolic 5'-nucleotidase 3B, Cytosolic 5'-nucleotidase III-like protein, and N(7)-methylguanylate 5'-phosphatase, plays a crucial role in cellular metabolism. It specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate, safeguarding against the undesired salvage and incorporation of m(7)GMP into nucleic acids. This enzyme also exhibits weak activity towards CMP, with UMP and purine nucleotides being poor substrates.
Therapeutic significance:
Understanding the role of 7-methylguanosine phosphate-specific 5'-nucleotidase could open doors to potential therapeutic strategies, offering insights into novel approaches for targeting metabolic pathways in disease contexts.